Have you ever considered fasting? Perhaps even if just for a mere day you should give it a go, especially in light of this new information.
A new study that was published just last month in the journal Cell Stem Cell has brought forth a lot of new information in regards to the world of stem cell regeneration. Researchers found that fasting for a mere 24 hours would be more than enough to work towards regenerating stem cells in the gut. Based on this, there is potential for age-related loss of function to be reversed. Now, while this study was a mere ‘mice study’ it does open a lot of doors.
For this study, these researchers looked at both old and young mice. They studied the effects of fasting for 24 hours and checked to see what might have happened to their intestinal stem cells after having done so. What they found was completely unexpected.
It seems the mice after fasting for just one day went through a change within the cells. They stopped burning carbohydrates and began burning fat. Because the cells were relying on the fatty acids they began to function better. While this may be a bit confusing, it isn’t as complicated as it sounds.
The highlights and summary of their study go as follows:
“Fasting induces fatty acid oxidation (FAO) in the intestinal stem and progenitor cells.
Aging reduces ISC numbers and function, correlating with decreased FAo.
PPAR/CPT1a-mediated FAO augments ISC function in aging and during regeneration.
PPARδ agonists boost and restore ISC and progenitor function in young and old age.”
“Diet has a profound effect on tissue regeneration in diverse organisms, and low caloric states such as intermittent fasting have beneficial effects on organismal health and age-associated loss of tissue function. The role of adult stem and progenitor cells in responding to short-term fasting and whether such responses improve regeneration are not well studied. Here we show that a 24 hr fast augments intestinal stem cell (ISC) function in young and aged mice by inducing a fatty acid oxidation (FAO) program and that pharmacological activation of this program mimics many effects of fasting. Acute genetic disruption of Cpt1a, the rate-limiting enzyme in FAO, abrogates ISC-enhancing effects of fasting, but long-term Cpt1a deletion decreases ISC numbers and function, implicating a role for FAO in ISC maintenance. These findings highlight a role for FAO in mediating pro-regenerative effects of fasting in intestinal biology, and they may represent a viable strategy for enhancing intestinal regeneration.”
This is not the first study to support the idea that fasting is able to help us heal our bodies. While fasting for too long is going to have a negative effect on you if done correctly it could be super beneficial.
Image via Collective-Evolution