It seems there might be a real cure for baldness after all. UCLA scientists believe they have things all figured out.
This research was actually published in the journal Nature Cell Biology. For this research, UCLA scientists worked to discover a new way to effectively activate the stem cells in the hair follicle to make hair grow. This research was led by scientists William Lowry and Heather Christofk. They believe that these findings will lead to a new drug that will promote hair growth for those suffering from alopecia as well as baldness in general.
Hair follicle stem cells are long-lived cells in the hair follicle that are present in the skin and produce hair as we age. These cells activate during a new hair cycle which can be regulated by a number of things. For many different reasons some people just have cells that fail to activate, this causes hair loss. These researchers were able to find that hair follicle stem cell metabolism is different than that of other skin cells.
“Our observations about hair follicle stem cell metabolism prompted us to examine whether genetically diminishing the entry of pyruvate into the mitochondria would force hair follicle stem cells to make more lactate and if that would activate the cells and grow hair more quickly.”
“Before no one knew that increasing or decreasing the lactate would have an effect on hair follicle stem cells.”
“Once we saw how altering lactate production in the mice influenced hair growth, it led us to look for potential drugs that could be applied to the skin and have the same effect.”
These researchers were actually able to identify 2 drugs that when applied to the skin of mice did influence the hair follicle stem cells. The first is called RCGD423 and the other is UK5099. The drugs were used in preclinical tests according to the UCLA website but have not yet been tested in human trials.
You can learn more about this interesting study in the video below. What do you think about all of this? I for one hope this does prove to be a cure so that all of those suffering from low self-esteem in regards to health conditions forcing them to lose their hair can find some peace of mind. More research is currently underway in regards to the use of UK5099 for hair loss, cross your fingers!